Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.54 |
| ▸ | SMO | Q99835 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476258 | 0.94 | OPRK1 (0.62) | OPRK1MAPK14SMOLCKMAP2K1 | |
| SCHEMBL2970301 | 0.93 | OPRK1 (0.61) | OPRK1MAPK14SMOLCKMAP2K1 | |
| SCHEMBL6484951 | 0.89 | MAPK14 (0.60) | OPRK1MAPK14SMOLCKMAP2K1 | |
| SCHEMBL7853300 | 0.89 | OPRK1 (0.56) | OPRK1MAPK14SMOLCKMAP2K1 | |
| SCHEMBL7809447 | 0.88 | OPRK1 (0.56) | OPRK1MAPK14SMONTRK1 | |
| SCHEMBL2971456 | 0.88 | OPRK1 (0.57) | OPRK1MAPK14SMOLCKMAP2K1 | |
| SCHEMBL6476055 | 0.88 | MAPK14 (0.67) | OPRK1MAPK14SMOLCKMAP2K1 | |
| SCHEMBL7807962 | 0.88 | MAPT (0.54) | MAPK14SMOLCKMAP2K1ALDH1A1 | |
| SCHEMBL7609472 | 0.86 | OPRK1 (0.69) | OPRK1MAPK14LCKMAP2K1NTRK1 | |
| SCHEMBL7804552 | 0.86 | OPRK1 (0.54) | OPRK1MAPK14SMONTRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | claimed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | claimed |
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |