Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610904 | 0.92 | MAPT (0.40) | MAPTKMT2AMEN1ATMNPC1 | |
| SCHEMBL7615837 | 0.89 | NQO1 (0.43) | NQO1MAPTKMT2AMEN1ATM | |
| SCHEMBL7611892 | 0.84 | MEN1 (0.52) | NQO1MAPTKMT2AMAOAMEN1 | |
| SCHEMBL7620353 | 0.83 | NQO1 (0.43) | NQO1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL7617634 | 0.82 | MAPT (0.51) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7616823 | 0.80 | KMT2A (0.41) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL7616962 | 0.80 | POLB (0.43) | NQO1MAPTKMT2AMEN1ATM | |
| SCHEMBL7609256 | 0.78 | KMT2A (0.46) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL7614212 | 0.77 | POLB (0.41) | NQO1MAPTKMT2AMEN1ATM | |
| SCHEMBL7640498 | 0.76 | CA12 (0.51) | NQO1MAPTKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869785-B1 | 4-HYDROXYCOUMARIN-3-CARBOXAMIDES FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS | UPJOHN CO (US) | 2002-08-28 | — | — | EP | claimed |