Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7616962 | 0.92 | POLB (0.43) | POLBMAPTHPGDCA1CA2 | |
| SCHEMBL9273892 | 0.85 | RAB9A (0.48) | HPGDKMT2AMEN1NPC1RAB9A | |
| SCHEMBL7610904 | 0.85 | MAPT (0.40) | POLBMAPTHPGDCA1CA2 | |
| SCHEMBL7618641 | 0.85 | MEN1 (0.52) | POLBMAPTHPGDKMT2AMEN1 | |
| SCHEMBL7617345 | 0.85 | CA1 (0.47) | POLBMAPTHPGDCA1CA2 | |
| SCHEMBL7613159 | 0.85 | MEN1 (0.43) | POLBMAPTHPGDCA1CA2 | |
| SCHEMBL9203805 | 0.85 | L3MBTL1 (0.54) | POLBHPGDKMT2AMEN1NPC1 | |
| SCHEMBL7612894 | 0.85 | CA1 (0.56) | CA1CA2CA12CA9 | |
| SCHEMBL9202732 | 0.84 | CA12 (0.51) | POLBMAPTHPGDKMT2AMEN1 | |
| SCHEMBL9200971 | 0.84 | MEN1 (0.43) | POLBMAPTHPGDCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869785-B1 | 4-HYDROXYCOUMARIN-3-CARBOXAMIDES FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS | UPJOHN CO (US) | 2002-08-28 | — | — | EP | claimed |
| EP-0869785-B1 | 4-HYDROXYCOUMARIN-3-CARBOXAMIDES FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS | UPJOHN CO (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-0869785-A1 | 4-HYDROXYCOUMARIN-3-CARBOXAMIDES FOR THE TREATMENT OF DIABETES MELLITUS | PHARMACIA & UPJOHN COMPANY (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997018808-A1 | 4-HYDROXYCOUMARIN-3-CARBOXAMIDES FOR THE TREATMENT OF DIABETES MELLITUS | PHARMACIA & UPJOHN COMPANY (US) | 1997-05-29 | — | — | WO | disclosed |