Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778706 | 0.82 | KMT2A (0.47) | SMN1; SMN2KMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL3283283 | 0.79 | KMT2A (0.60) | SMN1; SMN2KMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL7616044 | 0.76 | RIPK1 (0.73) | SMN1; SMN2KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL10837254 | 0.71 | ALDH1A1 (0.67) | SMN1; SMN2KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL3380546 | 0.70 | CYP2C19 (0.42) | SMN1; SMN2KMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL10876359 | 0.69 | CES1 (0.48) | SMN1; SMN2KMT2AMEN1CYP3A4CYP2C19 | |
| SCHEMBL11269635 | 0.69 | CES1 (0.43) | SMN1; SMN2KMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL7612868 | 0.69 | RIPK1 (0.48) | ALDH1A1RIPK1KDM4EHPGDMAPT | |
| SCHEMBL29682370 | 0.69 | RIPK1 (0.51) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL9508580 | 0.68 | POLB (0.63) | CYP3A4CYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002534440-A | — | — | 2002-10-15 | — | — | JP | claimed |
| EP-1143941-A3 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | Jomaa Pharmaka GmbH (DE) | 2002-02-06 | — | — | EP | claimed |
| EP-1143941-A2 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | Jomaa Pharmaka GmbH (DE) | 2001-10-17 | — | — | EP | claimed |
| WO-2000041473-A2 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | JOMAA PHARMAKA GMBH (DE) | 2000-07-20 | — | — | WO | claimed |
| EP-1143941-A3 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | Jomaa Pharmaka GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| EP-1143941-A2 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | Jomaa Pharmaka GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000041473-A2 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | JOMAA PHARMAKA GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |
| US-4405357-A | Herbicidal 3-isoxazolidinones and hydroxamic acids | FMC CORPORATION (US) | 1983-09-20 | — | — | US | disclosed |