Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LAP3 | P28838 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607704 | 0.87 | MME (0.44) | — | |
| SCHEMBL7610590 | 0.85 | CETP (0.43) | HPGDTSHRNPC1RAB9AMEN1 | |
| SCHEMBL7606709 | 0.83 | CETP (0.48) | CYP3A4TSHRMAPK1ALDH1A1CETP | |
| SCHEMBL7605254 | 0.82 | ACP3 (0.41) | HPGDTSHRACP3MEN1KMT2A | |
| SCHEMBL27519157 | 0.79 | CETP (0.42) | LAP3HPGDHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL28294425 | 0.77 | HPGD (0.51) | HPGDCYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL18300625 | 0.76 | HSD17B10 (0.50) | HPGDCYP3A4TSHRMAPK1HSD17B10 | |
| SCHEMBL2600694 | 0.75 | ALDH1A1 (0.60) | HPGDCYP3A4TSHRANPEPMAPK1 | |
| SCHEMBL17761604 | 0.75 | ALDH1A1 (0.60) | HPGDCYP3A4TSHRANPEPMAPK1 | |
| SCHEMBL517463 | 0.75 | ALDH1A1 (0.60) | HPGDCYP3A4TSHRANPEPMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |