Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT1 | P24752 | 1/20 | 0.61 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.59 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7608958 | 0.96 | ACAT1 (0.67) | ACAT1SOAT1PTAFR | |
| SCHEMBL7607473 | 0.95 | ACAT1 (0.64) | ACAT1SOAT1PTAFR | |
| SCHEMBL7606659 | 0.94 | ACAT1 (0.57) | ACAT1SOAT1PTAFRGPR132GAA | |
| SCHEMBL7607634 | 0.94 | ACAT1 (0.58) | ACAT1SOAT1PTAFRGPR132 | |
| SCHEMBL8329032 | 0.93 | ACAT1 (0.64) | ACAT1SOAT1GPR132 | |
| SCHEMBL7606756 | 0.92 | ACAT1 (0.53) | ACAT1SOAT1PTAFRGPR132GAA | |
| SCHEMBL7613958 | 0.91 | SOAT1 (0.58) | ACAT1SOAT1PTAFRGPR132 | |
| SCHEMBL7610602 | 0.91 | ACAT1 (0.59) | ACAT1SOAT1PTAFR | |
| SCHEMBL7618592 | 0.89 | ACAT1 (0.68) | ACAT1SOAT1 | |
| SCHEMBL5990213 | 0.89 | ACAT1 (0.70) | ACAT1SOAT1GPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420381-B1 | ACYL-COA: CHOLESTEROL ACYL TRANSFERASE (ACAT) INHIBITORY ACTIVITY, AND IS USEFUL AS AN AGENT FOR TREATMENT OF HYPERLIPIDEMIA AND ATHEROSCLEROSIS. | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1104763-A1 | NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-06 | — | — | EP | disclosed |