Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | C5 | P01031 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | EBP | Q15125 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7612430 | 0.95 | C5 (0.48) | MCHR1BCHEACHEC5SIGMAR1 | |
| SCHEMBL7609710 | 0.86 | MCHR1 (0.58) | MCHR1C5SLC2A1HTR2C | |
| SCHEMBL7609706 | 0.86 | MCHR1 (0.58) | MCHR1C5SLC2A1HTR2C | |
| SCHEMBL7606995 | 0.84 | ACHE (0.40) | BCHEACHEPOLB | |
| SCHEMBL7612419 | 0.84 | MCHR1 (0.52) | MCHR1BCHEACHEC5SLC2A1 | |
| SCHEMBL7612426 | 0.84 | MCHR1 (0.52) | MCHR1BCHEACHEC5SLC2A1 | |
| SCHEMBL7613677 | 0.82 | BCHE (0.65) | BCHEACHESLC2A1 | |
| SCHEMBL7618583 | 0.81 | MCHR1 (0.54) | MCHR1C5SIGMAR1EBPTMEM97 | |
| SCHEMBL6921907 | 0.77 | MCHR1 (0.80) | MCHR1HTR2C | |
| SCHEMBL6898088 | 0.77 | MCHR1 (0.67) | MCHR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100495-A4 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORP (US) | 2002-09-25 | — | — | EP | claimed |
| JP-2002521441-A | — | — | 2002-07-16 | — | — | JP | claimed |
| EP-1100495-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-23 | — | — | EP | claimed |
| WO-2000006153-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | claimed |