Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | NT5E | P21589 | 1/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.77 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.63 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.59 |
| ▸ | CA5A | P35218 | 1/20 | 0.58 |
| ▸ | PDE2A | O00408 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610042 | 1.00 | LMNA (0.77) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL8619636 | 0.91 | ADORA2A (0.64) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL8619626 | 0.91 | ADORA2A (0.64) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL7611839 | 0.90 | LMNA (0.71) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL7611831 | 0.90 | LMNA (0.71) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL1527213 | 0.89 | ADORA2A (0.66) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL12150807 | 0.89 | ADORA2A (0.66) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL1527211 | 0.89 | ADORA2A (0.66) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL12031300 | 0.89 | ADORA2A (0.66) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL12300482 | 0.89 | ADORA2A (0.66) | LMNANT5EHIF1AADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4370136-A2 | SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES | Alnylam Pharmaceuticals, Inc. (US) | 2024-05-22 | — | — | EP | disclosed |
| WO-2023288045-A2 | SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |
| US-20210189392-A1 | S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS | ALIGOS THERAPEUTICS, INC. | 2021-06-24 | — | — | US | disclosed |
| EP-1198592-A4 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS INC (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1198592-A1 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS, INC. (US) | 2002-04-24 | — | — | EP | disclosed |
| US-6175004-B1 | REACTING AN OLIGONUCLEOTIDE COMPRISING A HALOGENATED PURINE NUCLEOSIDE WITH AMINE; FOR STRONGER HYBRIDIZATION; DIAGNOSIS; GENETIC ENGINEERING; ANTISENSE AGENTS | ISIS PHARMACEUTICALS, INC. | 2001-01-16 | — | — | US | disclosed |
| WO-2001002608-A1 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |
| US-5773603-A | ADENOSINE DEAMINASE INHIBITOR | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| US-5705491-A | Adenosine deaminase inhibitor | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| EP-0601322-A2 | Adenosindeaminase inhibitor | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1994-06-15 | — | — | EP | disclosed |
| EP-0269574-B1 | NOVEL ADENOSINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS AN ACTIVE INGREDIENT | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4843066-A | HYPOTENSIVE AGENTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-27 | — | — | US | disclosed |