Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624570 | 0.98 | GABRA1 (0.47) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL18136 | 0.83 | GABRA1 (0.56) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| Bromide SCHEMBL28443429 | 0.81 | GABRA1 (0.45) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL1326258 | 0.79 | GABRA1 (0.35) | GABRA1GABRB2 | |
| SCHEMBL170640 | 0.79 | GABRA1 (0.47) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL2362269 | 0.77 | GABRA1 (0.61) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL3265432 | 0.77 | GABRA1 (0.45) | GABRA1GABRB2AKR1B1L3MBTL1ALDH1A1 | |
| SCHEMBL4170461 | 0.77 | GABRA1 (0.50) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL12076599 | 0.76 | GABRA1 (0.54) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL10625097 | 0.75 | GABRA1 (0.48) | GABRA1GABRB2AKR1B1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020498-B1 | Preparation of permanent color inks from water-soluble colorants using specific phosphonium salts | HEWLETT PACKARD CO (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6248161-B1 | Preparation of permanent color inks from water-soluble colorants using specific phosphonium salts | HEWLETT-PACKARD COMPANY | 2001-06-19 | — | — | US | disclosed |
| EP-1020498-A1 | Preparation of permanent color inks from water-soluble colorants using specific phosphonium salts | Hewlett-Packard Company (US) | 2000-07-19 | — | — | EP | disclosed |