Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611215 | 1.00 | MAPT (0.45) | MAPTNTRK1NTRK3NTRK2KDR | |
| SCHEMBL7723563 | 0.85 | RAF1 (0.43) | MAPTNTRK1POLBRAB9AXBP1 | |
| SCHEMBL5462483 | 0.81 | MAOA (0.45) | MAPTNTRK1NTRK3NTRK2KDR | |
| SCHEMBL5462488 | 0.81 | MAOA (0.45) | MAPTNTRK1NTRK3NTRK2KDR | |
| SCHEMBL7606283 | 0.78 | JAK3 (0.41) | MAPTNTRK1NTRK3NTRK2KDR | |
| SCHEMBL7606291 | 0.78 | JAK3 (0.41) | MAPTNTRK1NTRK3NTRK2KDR | |
| SCHEMBL7609675 | 0.76 | NTRK1 (0.46) | MAPTNTRK1NTRK3NTRK2KDR | |
| SCHEMBL7609671 | 0.76 | NTRK1 (0.46) | MAPTNTRK1NTRK3NTRK2KDR | |
| SCHEMBL7606270 | 0.75 | MAPT (0.40) | MAPTNTRK1MEN1KMT2APOLB | |
| SCHEMBL5421094 | 0.75 | RET (0.40) | MAPTMEN1RETCDK2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020099071-A1 | Protein tyrosine kinase and protein serin/threonine kinase inhibitory activity; anticancer agents; treating chemotherapy induced alopecia | GLENNON KIMBERLEY CAROLINE (US) | 2002-07-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099071-A1 | Protein tyrosine kinase and protein serin/threonine kinase inhibitory activity; anticancer agents; treating chemotherapy induced alopecia | PRKDC, PRKX, BMX | MAPT 2317/4885NTRK1 1095/4885NTRK3 543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.