Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606283 | 0.86 | JAK3 (0.41) | NTRK1MAPTPOLBRAB9AFLT3 | |
| SCHEMBL7606291 | 0.86 | JAK3 (0.41) | NTRK1MAPTPOLBRAB9AFLT3 | |
| SCHEMBL7611215 | 0.85 | MAPT (0.45) | NTRK1MAPTPOLBRAB9AXBP1 | |
| SCHEMBL7611213 | 0.85 | MAPT (0.45) | NTRK1MAPTPOLBRAB9AXBP1 | |
| SCHEMBL7609675 | 0.85 | NTRK1 (0.46) | RAF1NTRK1MAPTPOLBRAB9A | |
| SCHEMBL7609671 | 0.85 | NTRK1 (0.46) | RAF1NTRK1MAPTPOLBRAB9A | |
| SCHEMBL7606270 | 0.83 | MAPT (0.40) | NTRK1MAPTPOLBRAB9AXBP1 | |
| SCHEMBL5462483 | 0.81 | MAOA (0.45) | NTRK1MAPTPOLBRAB9AFLT3 | |
| SCHEMBL5462488 | 0.81 | MAOA (0.45) | NTRK1MAPTPOLBRAB9AFLT3 | |
| SCHEMBL7612207 | 0.80 | MAPT (0.35) | NTRK1MAPTPOLBRAB9AXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | claimed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | claimed |