Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10724742 | 0.85 | LTA4H (0.40) | LTA4HCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL5503141 | 0.81 | LTA4H (0.41) | LTA4HSLC6A4TSHRALDH1A1MTNR1A | |
| SCHEMBL2186074 | 0.80 | CA4 (0.42) | LTA4HCHRNB2CHRNB4CHRNA3CHRNA7 | |
| Ammonia Solution, Strong SCHEMBL9245393 | 0.78 | LTA4H (0.40) | LTA4HCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL4833131 | 0.78 | KDM4E (0.39) | CHRNB4CHRNA3KCNA3GAASLC6A4 | |
| SCHEMBL11300899 | 0.77 | TSHR (0.41) | LTA4HCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL11143140 | 0.77 | CA4 (0.44) | LTA4HCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7931227 | 0.75 | CA4 (0.35) | LTA4HSLC6A4TSHRALDH1A1MTNR1A | |
| SCHEMBL15509335 | 0.74 | LTA4H (0.38) | LTA4HGAASLC6A4TSHRALDH1A1 | |
| SCHEMBL11658593 | 0.72 | SLC6A4 (0.39) | LTA4HKCNA3SLC6A4TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858445-B1 | NEW [(3-ALKOXY-PHENOXY)-ETHYL]-DIALKYLAMINE DERIVATIVES AND THEIR USE AS LOCAL ANAESTHETICS | ASTRAZENECA AB (SE) | 2002-03-27 | — | — | EP | disclosed |