Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.56 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145692 | 0.84 | NLRP3 (0.60) | NLRP3ACLYGSTO1 | |
| SCHEMBL7138916 | 0.83 | NLRP3 (0.67) | NLRP3ACLYGSTO1 | |
| SCHEMBL19519038 | 0.77 | NLRP3 (0.78) | NLRP3FBP1GSTO1 | |
| SCHEMBL7614951 | 0.77 | NLRP3 (0.59) | NLRP3FBP1GSTO1 | |
| SCHEMBL19518818 | 0.76 | NLRP3 (0.72) | NLRP3GSTO1 | |
| SCHEMBL30406478 | 0.76 | NLRP3 (0.72) | NLRP3GSTO1 | |
| SCHEMBL19518827 | 0.73 | NLRP3 (0.69) | NLRP3FBP1GSTO1 | |
| SCHEMBL7142139 | 0.73 | NLRP3 (0.79) | NLRP3FBP1 | |
| SCHEMBL7137692 | 0.73 | NLRP3 (0.61) | NLRP3FBP1 | |
| SCHEMBL20636322 | 0.73 | NLRP3 (0.52) | NLRP3GSTO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214087-A1 | COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE | Pfizer Products Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019390-A1 | COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-03-22 | — | — | WO | disclosed |