Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.59 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137701 | 0.83 | NLRP3 (0.69) | NLRP3GSTO1ALDH1A1LMNATSHR | |
| SCHEMBL7135756 | 0.82 | NLRP3 (0.62) | NLRP3GSTO1ALDH1A1LMNATSHR | |
| SCHEMBL18029590 | 0.78 | NLRP3 (0.79) | NLRP3MEN1KMT2AFBP1 | |
| SCHEMBL31135852 | 0.78 | NLRP3 (0.79) | NLRP3MEN1KMT2AFBP1 | |
| SCHEMBL18029610 | 0.78 | NLRP3 (0.68) | NLRP3FBP1 | |
| SCHEMBL7613834 | 0.78 | NLRP3 (0.57) | NLRP3GSTO1ALDH1A1LMNATSHR | |
| SCHEMBL7611963 | 0.77 | NLRP3 (0.56) | NLRP3GSTO1FBP1 | |
| SCHEMBL7140940 | 0.76 | NLRP3 (0.69) | NLRP3KMT2AFBP1 | |
| SCHEMBL6555763 | 0.76 | NLRP3 (0.76) | NLRP3FBP1 | |
| SCHEMBL7137330 | 0.76 | NLRP3 (0.76) | NLRP3FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214087-A1 | COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE | Pfizer Products Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019390-A1 | COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-03-22 | — | — | WO | disclosed |