Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31361386 | 0.82 | MAPT (0.58) | MAPTKMT2AMEN1CA1CA2 | |
| SCHEMBL28673039 | 0.82 | MAPT (0.58) | MAPTKMT2AMEN1CA1CA2 | |
| SCHEMBL17512372 | 0.81 | MAPT (0.50) | MAPTKMT2AMEN1CA1CA2 | |
| SCHEMBL27639258 | 0.78 | MAPT (0.54) | MAPTKMT2AMEN1CA1CA2 | |
| Veratric Acid Methyl Ester SCHEMBL29573244 | 0.76 | MAPT (0.86) | MAPTKMT2AMEN1CA1CA2 | |
| Veratric Acid Methyl Ester SCHEMBL2050732 | 0.76 | MAPT (0.86) | MAPTKMT2AMEN1CA1CA2 | |
| SCHEMBL10239573 | 0.76 | MAPT (0.58) | MAPTKMT2AMEN1CA1CA2 | |
| SCHEMBL7614930 | 0.75 | ALDH1A1 (0.55) | MAPTKMT2AMEN1CA1CA2 | |
| SCHEMBL28663604 | 0.74 | MAPT (0.66) | MAPTKMT2AMEN1CA1CA2 | |
| SCHEMBL6568018 | 0.74 | MAPT (0.66) | MAPTKMT2AMEN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6433199-B1 | ANTITUMOR, ANTICANCER AGENTS | SHIONOGI BIORESEARCH CORPORATION | 2002-08-13 | — | — | US | disclosed |
| US-5969133-A | Bioreductive cytotoxic agents | SHIONGI BIORESEARCH CORP. (US) | 1999-10-19 | — | — | US | disclosed |