⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305978 | 0.86 | — | — | |
| SCHEMBL13507382 | 0.76 | ALDH1A1 (0.30) | — | |
| SCHEMBL2039024 | 0.74 | — | — | |
| SCHEMBL762384 | 0.74 | — | — | |
| SCHEMBL30285577 | 0.72 | — | — | |
| SCHEMBL15400817 | 0.72 | FAAH (0.31) | — | |
| SCHEMBL8305610 | 0.70 | — | — | |
| SCHEMBL4695460 | 0.70 | — | — | |
| SCHEMBL12395205 | 0.70 | — | — | |
| SCHEMBL783287 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417143-A1 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1991-03-20 | — | — | EP | claimed |
| WO-1989011856-A2 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1989-12-14 | — | — | WO | claimed |
| WO-2023198141-A1 | COMPOUND CAPABLE OF REGULATING AND CONTROLLING ACTIVITY OF 15-PGDH, AND PREPARATION METHOD THEREFOR | 赛诺哈勃药业（成都）有限公司 | 2023-10-19 | — | — | WO | disclosed |
| CN-114206861-A | Fused heteroaryl compounds useful as RIPK1 inhibitors | 比西切姆有限公司 | 2022-03-18 | — | — | CN | disclosed |
| US-20200140436-A1 | LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-05-07 | — | — | US | disclosed |
| US-9975891-B2 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-22 | — | — | US | disclosed |
| US-9975891-B2 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-22 | — | — | US | disclosed |
| CN-107001346-A | The base of 1 oxo, 1,2 dihydro-isoquinoline 7 bases of thiophene 2 of substitution (5) sulfonamide compounds, the preparation for containing those compounds and their purposes as AICARFT inhibitor in treating cancer | 伊莱利利公司 | 2017-08-01 | — | — | CN | disclosed |
| US-20170050964-A1 | LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2017-02-23 | — | — | US | disclosed |
| US-20170050964-A1 | LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2017-02-23 | — | — | US | disclosed |
| US-20140113892-A1 | LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-04-24 | — | — | US | disclosed |
| US-20070129361-A1 | LACTAM-CONTAINING DIAMINOALKYL, Beta-AMINOACIDS, Alpha-AMINOACIDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | QIAO JENNIFER X | 2007-06-07 | — | — | US | disclosed |
| US-20070099922-A1 | SULFONYLAMINOVALEROLACTAMS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | HAN WEI | 2007-05-03 | — | — | US | disclosed |
| US-7205318-B2 | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-17 | — | — | US | disclosed |
| US-7205318-B2 | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-17 | — | — | US | disclosed |
| US-7199149-B2 | Monocyclic and bicyclic lactams as factor Xa inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-04-03 | — | — | US | disclosed |
| US-7169795-B2 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
| WO-2004082687-A1 | LACTAM-CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-09-30 | — | — | WO | disclosed |
| EP-0417143-A1 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1991-03-20 | — | — | EP | disclosed |
| WO-1989011856-A2 | CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL | THE UPJOHN COMPANY (US) | 1989-12-14 | — | — | WO | disclosed |