Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 4/20 | 0.43 |
| ▸ | CES1 | P23141 | 4/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.40 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PPARD | Q03181 | 6/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PAM | P19021 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9164814 | 0.98 | KMT2A (0.48) | KMT2AMAPTCES2CES1HAO1 | |
| SCHEMBL11716770 | 0.98 | KMT2A (0.48) | KMT2AMAPTCES2CES1HAO1 | |
| SCHEMBL7947732 | 0.98 | KMT2A (0.48) | KMT2AMAPTCES2CES1HAO1 | |
| SCHEMBL7614748 | 0.86 | KMT2A (0.47) | KMT2AMAPTCES2CES1AKR1B1 | |
| SCHEMBL28661379 | 0.85 | ALDH1A1 (0.37) | CES2CES1TSHRALDH1A1 | |
| SCHEMBL9164807 | 0.84 | KMT2A (0.50) | KMT2AMAPTCES2CES1HAO1 | |
| SCHEMBL7947728 | 0.84 | KMT2A (0.50) | KMT2AMAPTCES2CES1HAO1 | |
| SCHEMBL11716766 | 0.84 | KMT2A (0.50) | KMT2AMAPTCES2CES1HAO1 | |
| SCHEMBL9157111 | 0.79 | ALDH1A1 (0.50) | TSHRALDH1A1 | |
| SCHEMBL10636366 | 0.79 | KDM4C (0.36) | KMT2ATSHRPTPN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4535179-A | Synthesis of bicyclic and tricyclic 7-oxa prostaglandin endoperoxide analogs via oxypalladation of norbornadiene | IOWA STATE UNIVERSITY RESEARCH FOUNDATION INC. (US) | 1985-08-13 | — | — | US | claimed |
| EP-4396271-A1 | COMPOSITION FOR POLYURETHANE FOAM, FOAM PREPARED THEREFROM AND A METHOD THEREOF | Momentive Performance Materials Inc. (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034354-A1 | COMPOSITION FOR POLYURETHANE FOAM, FOAM PREPARED THEREFROM AND A METHOD THEREOF | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| CN-113292419-A | Method for preparing treprostinil | 奇诺因药物和化学工厂私人有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-112979599-A | Preparation method of carboprost tromethamine intermediate | 河北赛谱睿思医药科技有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-107001221-B | Method for preparing treprostinil | 奇诺因药物和化学工厂私人有限公司 | 2021-05-25 | — | — | CN | disclosed |
| CN-107802623-B | Difluorolactam compositions for EP 4-mediated bone-related diseases and disorders | 开曼化学股份有限公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-106748951-B | Difluorolactam compounds as EP4 receptor selective agonists for use in the treatment of EP4 mediated diseases and conditions | 开曼化学股份有限公司 | 2020-07-24 | — | — | CN | disclosed |
| US-6452039-B1 | PROSTANOIC ACID DERIVATIVE WHEREIN THE ALPHA CHAIN HAS EIGHT OR MORE SKELETAL CARBON ATOMS; EXTREMELY STRONG ACTION; HYPERTENSION, ASTHMA, DIABETES, ARTERIAL SCLEROSIS, RENAL FAILURE, CARDIAC INFARCTION, ANGINA PECTORIS | SUCAMPO AG (CH) | 2002-09-17 | — | — | US | disclosed |
| EP-0857718-B1 | ENDOTHELIN ANTAGONIST | SUCAMPO AG (CH) | 2002-08-14 | — | — | EP | disclosed |
| US-5013862-A | Prostanoids and synthesis thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 1991-05-07 | — | — | US | disclosed |
| US-4855437-A | Prostanoids and synthesis thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 1989-08-08 | — | — | US | disclosed |
| US-4535179-A | Synthesis of bicyclic and tricyclic 7-oxa prostaglandin endoperoxide analogs via oxypalladation of norbornadiene | IOWA STATE UNIVERSITY RESEARCH FOUNDATION INC. (US) | 1985-08-13 | — | — | US | disclosed |
| EP-0079694-A1 | 7-Oxabicyclopheptane and 7-oxabicycloheptene compounds | E.R. Squibb & Sons, Inc. (US) | 1983-05-25 | — | — | EP | disclosed |
| US-4338466-A | PRECURSORS FOR OLIGOMERS EXHIBITING PROTECTION FOR OXIDATIVE PHOSPHORYLATION OF DEGENERATED MITOCHONDRIA | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1982-07-06 | — | — | US | disclosed |
| US-4159386-A | Synthesis of cyclopentanol | HOFFMANN-LA ROCHE INC. (US) | 1979-06-26 | — | — | US | disclosed |
| US-4133817-A | 11-Oxa-prostaglandin analogs | CHEMBRO HOLDINGS (PROPRIETARY) LIMITED (ZA) | 1979-01-09 | — | — | US | disclosed |
| US-4036857-A | TRANQUILIZERS, ANTIDEPRESSANTS | SHARPS ASSOCIATES (US) | 1977-07-19 | — | — | US | disclosed |
| US-4010169-A | (E)-4-Hydroxy-11,15-dioxoprosta-8(12),13-dien-1-oic acid γ-lactones | G. D. SEARLE & CO. (US) | 1977-03-01 | — | — | US | disclosed |
| US-3953470-A | Substituted prostaglandin derivatives | SYNTEX (U.S.A.) INC. (US) | 1976-04-27 | — | — | US | disclosed |