Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT1 | P24752 | 1/20 | 0.51 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606799 | 0.85 | ACAT1 (0.54) | ACAT1SOAT1MAPTPDE4APDE4B | |
| SCHEMBL7611737 | 0.85 | ACAT1 (0.53) | ACAT1SOAT1MAPTPDE4APDE4B | |
| SCHEMBL29427709 | 0.81 | ACAT1 (0.70) | ACAT1SOAT1 | |
| SCHEMBL5990213 | 0.81 | ACAT1 (0.70) | ACAT1SOAT1 | |
| SCHEMBL7611252 | 0.80 | ACAT1 (0.54) | ACAT1SOAT1 | |
| SCHEMBL7642220 | 0.79 | ACAT1 (0.71) | ACAT1SOAT1 | |
| SCHEMBL7608958 | 0.77 | ACAT1 (0.67) | ACAT1SOAT1 | |
| SCHEMBL7614247 | 0.77 | ACAT1 (0.64) | ACAT1SOAT1 | |
| SCHEMBL7612274 | 0.77 | ACAT1 (0.56) | ACAT1SOAT1 | |
| SCHEMBL8329032 | 0.76 | ACAT1 (0.64) | ACAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420381-B1 | ACYL-COA: CHOLESTEROL ACYL TRANSFERASE (ACAT) INHIBITORY ACTIVITY, AND IS USEFUL AS AN AGENT FOR TREATMENT OF HYPERLIPIDEMIA AND ATHEROSCLEROSIS. | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1104763-A1 | NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-06 | — | — | EP | disclosed |