SCHEMBL7615845

SCHEMBL7615845

CCOC(CN1C(=O)/C(=N\OCc2ccccc2)c2ccccc21)OCC

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.49
MEN1 O00255 1/20 0.49
MAPT P10636 6/20 0.45
NPSR1 Q6W5P4 3/20 0.45
TUBB4A P04350 2/20 0.44
TUBB P07437 2/20 0.44
TUBA3C P0DPH7 2/20 0.44
TUBA1B P68363 2/20 0.44
TUBA4A P68366 2/20 0.44
TUBB4B P68371 2/20 0.44
TUBB3 Q13509 2/20 0.44
TUBB2A Q13885 2/20 0.44
TUBB8 Q3ZCM7 2/20 0.44
TUBA3E Q6PEY2 2/20 0.44
TUBA1A Q71U36 2/20 0.44
TUBA1C Q9BQE3 2/20 0.44
TUBB6 Q9BUF5 2/20 0.44
TUBB2B Q9BVA1 2/20 0.44
TUBB1 Q9H4B7 2/20 0.44
ALDH1A1 P00352 10/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7615847 1.00 KMT2A (0.49) KMT2AMEN1MAPTNPSR1TUBB4A
SCHEMBL7614835 0.84 KMT2A (0.45) KMT2AMEN1MAPTNPSR1ALDH1A1
SCHEMBL7614839 0.84 KMT2A (0.45) KMT2AMEN1MAPTNPSR1ALDH1A1
SCHEMBL6599294 0.81 ALDH1A1 (0.43) KMT2AMEN1MAPTNPSR1ALDH1A1
SCHEMBL6599293 0.81 ALDH1A1 (0.43) KMT2AMEN1MAPTNPSR1ALDH1A1
SCHEMBL25706953 0.76 KMT2A (0.58) KMT2AMEN1MAPTNPSR1TUBB4A
SCHEMBL7612012 0.76 CES1 (0.56) KMT2AMEN1ALDH1A1ALDH2ALDH3A1
SCHEMBL27450383 0.72 NPC1 (0.34) KMT2AMEN1TUBB4ATUBBTUBA3C
SCHEMBL563821 0.71 KMT2A (0.47) KMT2AALDH1A1PKMTSHRHPGD
SCHEMBL7740953 0.70 ALDH1A1 (0.45) KMT2AMEN1MAPTNPSR1TUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0685463-B1 INDOLIN-2-ONE DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2002-05-22 EP disclosed
US-6207836-B1 Indolin-2-one derivatives CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-03-27 US disclosed
US-6127544-A 1-SUBSTITUTED-3-UREIDO-INDOLIN-2-ONES WHICH EXHIBIT SELECTIVE ANTAGONISM AGAINST GASTRIN RECEPTORS WITHOUT CAUSING SIDE EFFECTS ATTRIBUTED TO CCK-A RECEPTOR ANTAGONISM; SUCH AS FOR TREATMENT OF PEPTIC ULCERS, GASTRITIS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2000-10-03 US disclosed
US-6114536-A ANTAGONISM AGAINST GASTRIN RECEPTORS WITHOUT CAUSING SIDE EFFECTS ATTRIBUTED TO CCK-A RECEPTOR ANTAGONISM AND ARE USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES OF DIGESTIVE ORGANS, SUCH AS PEPTIC ULCER, GASTRITIS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2000-09-05 US disclosed
US-6031111-A Indolin-2-one derivatives CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2000-02-29 US disclosed
US-5952511-A EXHIBITS SELECTIVE ANTAGONISM AGAINST GASTRIN RECEPTOR WITHOUT CAUSING SIDE EFFECTS ATTRIBUTED TO GASTRIN RECEPTOR ANTAGONISM AND USEFUL FOR TREATING PEPTIC ULCER, GASTRITIS, REFLUX ESOPHAGITIS AND ZOLLINGER-ELLISON SYNDROME CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1999-09-14 US disclosed
EP-0685463-A1 INDOLIN-2-ONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1995-12-06 EP disclosed