Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.43 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599293 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PKMKDM4EKMT2ALMNA | |
| SCHEMBL7614835 | 0.86 | KMT2A (0.45) | ALDH1A1PKMKDM4EKMT2ALMNA | |
| SCHEMBL7614839 | 0.86 | KMT2A (0.45) | ALDH1A1PKMKDM4EKMT2ALMNA | |
| SCHEMBL7612012 | 0.82 | CES1 (0.56) | ALDH1A1KMT2AMEN1AGTR1ALDH2 | |
| SCHEMBL7615847 | 0.81 | KMT2A (0.49) | ALDH1A1PKMKDM4EKMT2ALMNA | |
| SCHEMBL7615845 | 0.81 | KMT2A (0.49) | ALDH1A1PKMKDM4EKMT2ALMNA | |
| SCHEMBL7564533 | 0.80 | CA12 (0.56) | ALDH1A1PKMKDM4EKMT2ALMNA | |
| SCHEMBL7564529 | 0.80 | CA12 (0.56) | ALDH1A1PKMKDM4EKMT2ALMNA | |
| SCHEMBL7589906 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4EKMT2ALMNAMAPT | |
| SCHEMBL9301105 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4EKMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156037-B1 | CHONDRONGENESIS PROMOTORS AND INDOLIN-2-ONE DERIVATIVES | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-6716628-B2 | CARTILAGE REPAIR AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-04-06 | — | — | US | disclosed |
| US-20030187054-A1 | Preparations for chondrogenesis | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-10-02 | — | — | US | disclosed |
| US-20030119896-A1 | Chondrogenesis promoters and indolin-2-one derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-06-26 | — | — | US | disclosed |
| US-6500854-B1 | CHONDROCYTE PROLIFERATORS SUCH AS 1-(2,2-DIETHOXYETHYL)-3-(N'-(4-HYDROXYMETHYLPHENYL)UREIDO)-3-((4 -METHYLPHENYL)AMINO-CARBONYLMETHYL)INDOLIN-2-ONE FOR PROPHYLAXIS BONE DISORDERS | CHUGAI SEI YAKU KABUSHIKI KAISHA (JP) | 2002-12-31 | — | — | US | disclosed |
| EP-1266664-A1 | PREPARATIONS FOR CHONDROGENESIS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-12-18 | — | — | EP | disclosed |
| EP-0685463-B1 | INDOLIN-2-ONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2002-05-22 | — | — | EP | disclosed |
| EP-1156037-A1 | CHONDRONGENESIS PROMOTORS AND INDOLIN-2-ONE DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-11-21 | — | — | EP | disclosed |
| US-6207836-B1 | Indolin-2-one derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-03-27 | — | — | US | disclosed |
| US-6127544-A | 1-SUBSTITUTED-3-UREIDO-INDOLIN-2-ONES WHICH EXHIBIT SELECTIVE ANTAGONISM AGAINST GASTRIN RECEPTORS WITHOUT CAUSING SIDE EFFECTS ATTRIBUTED TO CCK-A RECEPTOR ANTAGONISM; SUCH AS FOR TREATMENT OF PEPTIC ULCERS, GASTRITIS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-03 | — | — | US | disclosed |
| US-6114536-A | ANTAGONISM AGAINST GASTRIN RECEPTORS WITHOUT CAUSING SIDE EFFECTS ATTRIBUTED TO CCK-A RECEPTOR ANTAGONISM AND ARE USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES OF DIGESTIVE ORGANS, SUCH AS PEPTIC ULCER, GASTRITIS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-09-05 | — | — | US | disclosed |
| US-6031111-A | Indolin-2-one derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-02-29 | — | — | US | disclosed |
| CN-1046268-C | Indolin-2-one derivatives | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1999-11-10 | — | — | CN | disclosed |
| US-5952511-A | EXHIBITS SELECTIVE ANTAGONISM AGAINST GASTRIN RECEPTOR WITHOUT CAUSING SIDE EFFECTS ATTRIBUTED TO GASTRIN RECEPTOR ANTAGONISM AND USEFUL FOR TREATING PEPTIC ULCER, GASTRITIS, REFLUX ESOPHAGITIS AND ZOLLINGER-ELLISON SYNDROME | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0685463-A1 | INDOLIN-2-ONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1995-12-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187054-A1 | Preparations for chondrogenesis | COL2A1, BMP2, COL1A1 | ALDH1A1 104/4885PKM 3430/4885KDM4E 3290/4885 |
| US-20030119896-A1 | Chondrogenesis promoters and indolin-2-one derivatives | SOX18, BMP2, EBP | ALDH1A1 501/4885PKM 4154/4885KDM4E 982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.