Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 14/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7615984 | 1.00 | SLC6A2 (0.71) | SLC6A2KDM4EL3MBTL1 | |
| SCHEMBL7611595 | 0.87 | SLC6A2 (0.64) | SLC6A2 | |
| Maleic Acid SCHEMBL7613132 | 0.83 | SLC6A2 (0.80) | SLC6A2 | |
| Fumaric Acid SCHEMBL7613140 | 0.83 | SLC6A2 (0.80) | SLC6A2 | |
| Maleic Acid SCHEMBL9665039 | 0.83 | SLC6A2 (1.00) | SLC6A2 | |
| Fumaric Acid SCHEMBL9665047 | 0.83 | SLC6A2 (1.00) | SLC6A2 | |
| Maleic Acid SCHEMBL10571622 | 0.78 | SLC6A2 (0.63) | SLC6A2 | |
| Fumaric Acid SCHEMBL10571627 | 0.78 | SLC6A2 (0.63) | SLC6A2 | |
| Fumaric Acid SCHEMBL7613127 | 0.78 | SLC6A2 (0.80) | SLC6A2 | |
| Maleic Acid SCHEMBL7613124 | 0.78 | SLC6A2 (0.80) | SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840609-B1 | USE OF UNSUBSTITUTED AND SUBSTITUTED N-(PYRROL-1-YL)PYRIDINAMINES AS ANTICONVULSANT AGENTS | AVENTIS PHARMA INC (US) | 2002-06-05 | — | — | EP | disclosed |
| US-5776955-A | Use of unsubstituted and substituted n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents | HOECHST MARION ROUSSEL, INC. | 1998-07-07 | — | — | US | disclosed |
| EP-0840609-A1 | USE OF UNSUBSTITUTED AND SUBSTITUTED N-(PYRROL-1-YL)PYRIDINAMINES AS ANTICONVULSANT AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997004777-A1 | USE OFF UNSUBSTITUTED AND SUBSTITUTED N-(PYRROL-1-YL)PYRIDINAMINES AS ANTICONVULSANT AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-02-13 | — | — | WO | disclosed |