Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6441288 | 0.83 | EPHX1 (0.41) | KMT2ACES2CES1 | |
| SCHEMBL6445257 | 0.83 | EPHX1 (0.41) | KMT2ACES2CES1 | |
| SCHEMBL6443841 | 0.83 | EPHX1 (0.41) | KMT2ACES2CES1 | |
| SCHEMBL6443382 | 0.83 | EPHX1 (0.41) | KMT2ACES2CES1 | |
| SCHEMBL6442090 | 0.80 | TDP1 (0.41) | CYP3A4TDP1ESR1ESR2TP53 | |
| SCHEMBL14413267 | 0.76 | TDP1 (0.38) | CYP3A4TDP1ESR1ESR2CA12 | |
| SCHEMBL301087 | 0.75 | CYP3A4 (0.41) | CYP3A4TDP1ESR1ESR2TP53 | |
| SCHEMBL163845 | 0.75 | TDP1 (0.41) | CYP3A4TDP1ESR1ESR2TP53 | |
| Butane SCHEMBL8167331 | 0.75 | CYP3A4 (0.41) | CYP3A4TDP1ESR1ESR2TP53 | |
| SCHEMBL3997009 | 0.73 | TDP1 (0.39) | CYP3A4TDP1ESR1ESR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6437075-B1 | Polyurethane and polyurea biomaterials for use in medical devices | MEDTRONIC, INC. | 2002-08-20 | — | — | US | disclosed |
| US-6437076-B1 | Polyurethane and polyurea biomaterials for use in medical devices | MEDTRONIC, INC | 2002-08-20 | — | — | US | disclosed |
| EP-0875519-B1 | Polyurethane biomaterials for use in medical devices | MEDTRONIC INC (US) | 2001-07-04 | — | — | EP | disclosed |
| US-6149678-A | Polyurethane and polyurea biomaterials for use in medical devices | MEDTRONIC, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-6111052-A | CONTAINING SACRIFICIAL MOIETIES (E.G., SULFUR-CONTAINING OR PHOSPHORUS-CONTAINING MOIETIES) THAT PREFERENTIALLY OXIDIZE RELATIVE TO OTHER MOIETIES IN THE POLYMER | MEDTRONIC, INC. (US) | 2000-08-29 | — | — | US | disclosed |
| US-5986034-A | MEDICAL EQUIPMENT WITH CONNECTORS, SHEATHS AND CONDUCTORS | MEDTRONIC, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0875519-A1 | Biomaterials for use in medical devices | MEDTRONIC, INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| US-4187385-A | TITANIUM COMPONENT COPULVERIZED WITH ORGANOALUMINUM COMPOUND AND ETHYLENE OR A-OLEFINS, PARTICLE SIZE | MITSUI TOATSU CHEMICAL, INC. (JP) | 1980-02-05 | — | — | US | disclosed |