Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7618317 | 0.85 | ADRB1 (0.41) | TYRCYP3A4MAPTCA1CA2 | |
| SCHEMBL6395717 | 0.84 | ESR1 (0.34) | ESR1ESR2PDCD1CD274EGFR | |
| SCHEMBL7622352 | 0.81 | ESR1 (0.46) | ESR1ESR2PDCD1CD274TYR | |
| SCHEMBL7618836 | 0.81 | ESR1 (0.39) | ESR1ESR2TYRCYP3A4MAPT | |
| SCHEMBL6396454 | 0.80 | ESR1 (0.36) | ESR1ESR2PDCD1CD274EGFR | |
| SCHEMBL7622726 | 0.79 | ESR1 (0.37) | ESR1ESR2CYP3A4MAPTMEN1 | |
| SCHEMBL7615263 | 0.78 | ESR1 (0.42) | ESR1ESR2PDCD1CD274TYR | |
| SCHEMBL6404165 | 0.77 | ESR1 (0.46) | ESR1ESR2CYP3A4MAPTLMNA | |
| SCHEMBL6396759 | 0.75 | ESR1 (0.46) | ESR1ESR2PDCD1CD274CYP3A4 | |
| SCHEMBL6397044 | 0.75 | CYP3A4 (0.44) | ESR1ESR2PDCD1CD274CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175425-A2 | INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000043402-A2 | INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-07-27 | — | — | WO | disclosed |