Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15437890 | 0.97 | HDAC4 (0.62) | HDAC4HDAC2HDAC8HDAC6LMNA | |
| SCHEMBL5389905 | 0.97 | HDAC4 (0.62) | HDAC4HDAC2HDAC8HDAC6LMNA | |
| SCHEMBL10505011 | 0.83 | HDAC4 (0.48) | HDAC4HDAC2HDAC8HDAC6LMNA | |
| SCHEMBL21471576 | 0.79 | HDAC4 (1.00) | HDAC4HDAC2HDAC8HDAC6LMNA | |
| SCHEMBL2442343 | 0.79 | GSTP1 (0.62) | HDAC4HDAC2HDAC8HDAC6LMNA | |
| SCHEMBL7914987 | 0.79 | LMNA (0.55) | HDAC4HDAC2HDAC8HDAC6LMNA | |
| SCHEMBL10481639 | 0.78 | HDAC4 (0.77) | HDAC4HDAC2HDAC8HDAC6LMNA | |
| SCHEMBL16812115 | 0.78 | HDAC4 (0.71) | HDAC4HDAC2HDAC8LMNAMAPT | |
| SCHEMBL7905187 | 0.78 | ALDH1A1 (0.54) | HDAC4HDAC2HDAC8HDAC6LMNA | |
| SCHEMBL21447 | 0.77 | ALDH1A1 (0.61) | HDAC4HDAC2HDAC8HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790158-B2 | Substituted tropolone derivatives and methods of use | UNIVERSITY OF CONNECTICUT (US) | 2017-10-17 | — | — | US | disclosed |
| US-9790158-B2 | Substituted tropolone derivatives and methods of use | UNIVERSITY OF CONNECTICUT (US) | 2017-10-17 | — | — | US | disclosed |
| US-20150166448-A1 | Substituted Tropolone Derivatives and Methods of Use | UNIVERSITY OF CONNECTICUT | 2015-06-18 | — | — | US | disclosed |
| US-20150166448-A1 | Substituted Tropolone Derivatives and Methods of Use | UNIVERSITY OF CONNECTICUT | 2015-06-18 | — | — | US | disclosed |
| EP-0863890-B1 | 5-AMIDOMETHYL ALPHA, BETHA-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS | UPJOHN CO (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-0872903-B1 | Method for making hydrogen storage alloy powder and electrode comprising the alloy powder | SHINETSU CHEMICAL CO (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-6277519-B1 | QUENCHING AN ALLOY MELT; COMMINUTION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2001-08-21 | — | — | US | disclosed |
| US-6096144-A | TREATING WITH ACIDIC OR ALKALINE SOLUTION OF CONJUGATED UNSATURATED COMPOUND WITH AT LEAST 5 BONDS | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| US-5858571-A | TREATING A PULVERIZED HYDROGEN ABSORBING ALLOY WITH A SOLUTION COMPRISING A CONJUGATED UNSATURATED COMPOUND | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| EP-0872903-A1 | Method for making hydrogen storage alloy powder and electrode comprising the alloy powder | Shin-Etsu Chemical Co., Ltd. (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0863890-A1 | 5-AMIDOMETHYL ALPHA, BETHA-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |
| US-5708169-A | BACTERICIDES FOR TREATMENT OF GRAM POSITIVE INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| WO-1997010235-A1 | 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1997-03-20 | — | — | WO | disclosed |
| EP-0172427-B1 | PROCESS FOR PRODUCTION OF VINYL CHLORIDE POLYMER | Shin-Etsu Chemical Co., Ltd. (JP) | 1989-07-05 | — | — | EP | disclosed |
| US-4758639-A | Process for production of vinyl polymer | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1988-07-19 | — | — | US | disclosed |
| US-4757124-A | Suspension or emulsion polymerizing vinyl chloride monomer or mixture of vinyl chloride with vinyl monomer copolymerizable therewith in reactor with walls coated with antiscaling compound containing dye or pigments | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0172427-A2 | Process for production of vinyl chloride polymer | Shin-Etsu Chemical Co., Ltd. (JP) | 1986-02-26 | — | — | EP | disclosed |
| US-4539230-A | COATING WALLS WITH A CHELATE COMPOUND | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1985-09-03 | — | — | US | disclosed |
| EP-0126991-A1 | A method for preventing deposition of polymer scale and a coating agent therefor | Shin-Etsu Chemical Co., Ltd. (JP) | 1984-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166448-A1 | Substituted Tropolone Derivatives and Methods of Use | HDAC5, HDAC4, HDAC7 | HDAC4 2/4885HDAC2 10/4885HDAC8 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.