Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MC3R | P41968 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | PTGFR | P43088 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7616622 | 0.83 | PGR (0.34) | PGRADORA3ADRA2CSLC6A2HTR2B | |
| SCHEMBL7618196 | 0.81 | PTGFR (0.32) | TBXA2RPTGFRPTGER2 | |
| SCHEMBL7621015 | 0.75 | — | — | |
| SCHEMBL8822856 | 0.74 | MEN1 (0.42) | PDE4DTBXA2RPTGFRPTGER2 | |
| SCHEMBL8822932 | 0.74 | MEN1 (0.42) | PDE4DTBXA2RPTGFRPTGER2 | |
| SCHEMBL18022086 | 0.68 | PTGFR (0.53) | TBXA2RPTGFRPTGER2 | |
| SCHEMBL9849477 | 0.65 | MEN1 (0.37) | PDE4DTBXA2RPTGFRPTGER2 | |
| SCHEMBL8822848 | 0.65 | MEN1 (0.37) | PDE4DTBXA2RPTGFRPTGER2 | |
| SCHEMBL17460685 | 0.65 | PTGFR (0.53) | TBXA2RPTGFRPTGER2 | |
| SCHEMBL18023366 | 0.63 | PTGFR (0.49) | TBXA2RPTGFRPTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6452039-B1 | PROSTANOIC ACID DERIVATIVE WHEREIN THE ALPHA CHAIN HAS EIGHT OR MORE SKELETAL CARBON ATOMS; EXTREMELY STRONG ACTION; HYPERTENSION, ASTHMA, DIABETES, ARTERIAL SCLEROSIS, RENAL FAILURE, CARDIAC INFARCTION, ANGINA PECTORIS | SUCAMPO AG (CH) | 2002-09-17 | — | — | US | disclosed |
| EP-0857718-B1 | ENDOTHELIN ANTAGONIST | SUCAMPO AG (CH) | 2002-08-14 | — | — | EP | disclosed |
| US-6242485-B1 | ADMINISTERING PROSTANOIC ACID DERIVATIVE TO TREAT VISION, KIDNEY, CARDIOVASCULAR AND BRAIN DISORDERS; HYPOTENSIVE AND ANTIASTHMATIC AGENTS | R-TECH UENO (JP) | 2001-06-05 | — | — | US | disclosed |
| EP-0857718-A1 | ENDOTHELIN ANTAGONIST | R-Tech Ueno, Ltd. (JP) | 1998-08-12 | — | — | EP | disclosed |