Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.33 |
| ▸ | INPP5B | P32019 | 1/20 | 0.33 |
| ▸ | INPP5A | Q14642 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7619707 | 0.90 | POLB (0.37) | TDP1MAPK1MEN1KMT2AF2 | |
| SCHEMBL7617339 | 0.87 | RORC (0.34) | TDP1MAPK1MEN1KMT2AKDM4E | |
| SCHEMBL7619530 | 0.85 | INPPL1 (0.39) | TDP1MAPK1MEN1KMT2AKDM4E | |
| SCHEMBL7618762 | 0.82 | F2 (0.39) | TDP1F2KDM4EMAPTESR1 | |
| SCHEMBL7622726 | 0.81 | ESR1 (0.37) | TDP1MAPK1MEN1KMT2AF2 | |
| SCHEMBL7615263 | 0.80 | ESR1 (0.42) | MEN1KMT2AMAPTESR1ESR2 | |
| SCHEMBL6396820 | 0.80 | ESR1 (0.44) | TDP1MAPTESR1ESR2INPPL1 | |
| SCHEMBL7618825 | 0.80 | F2 (0.39) | TDP1F2KDM4EMAPTESR1 | |
| SCHEMBL6397735 | 0.77 | INPPL1 (0.35) | MEN1KMT2AMAPTESR1ESR2 | |
| SCHEMBL6398355 | 0.77 | ESR1 (0.34) | TDP1KDM4EESR1ESR2INPPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175425-A2 | INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000043402-A2 | INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-07-27 | — | — | WO | disclosed |