Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.57 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145342 | 0.95 | NLRP3 (0.62) | NLRP3CA2CA1HTTKMT2A | |
| SCHEMBL7613834 | 0.90 | NLRP3 (0.57) | NLRP3CA2CA1CA12CA9 | |
| SCHEMBL7619278 | 0.87 | NLRP3 (0.54) | NLRP3CA2CA1CA12CA7 | |
| SCHEMBL7135756 | 0.84 | NLRP3 (0.62) | NLRP3KMT2AFLT1FLT4KDR | |
| SCHEMBL7142667 | 0.84 | NLRP3 (0.74) | NLRP3CA2CA1CA12CA9 | |
| SCHEMBL7617403 | 0.83 | NLRP3 (0.66) | NLRP3CA2CA1CA12CA9 | |
| SCHEMBL7617320 | 0.82 | NLRP3 (0.60) | NLRP3CA2CA1CA12CA9 | |
| SCHEMBL7145367 | 0.82 | NLRP3 (0.59) | NLRP3KMT2AFLT1FLT4KDR | |
| SCHEMBL7140940 | 0.81 | NLRP3 (0.69) | NLRP3CA2CA1HTTKMT2A | |
| SCHEMBL7612024 | 0.81 | NLRP3 (0.69) | NLRP3CA2CA1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214087-A1 | COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE | Pfizer Products Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019390-A1 | COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-03-22 | — | — | WO | disclosed |