Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.59 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7619278 | 0.95 | NLRP3 (0.54) | NLRP3FLT1FLT4KDRLPAR1 | |
| SCHEMBL7137337 | 0.89 | NLRP3 (0.64) | NLRP3LPAR1 | |
| SCHEMBL7141504 | 0.86 | NLRP3 (0.66) | NLRP3FLT1FLT4KDRLPAR1 | |
| SCHEMBL7145342 | 0.86 | NLRP3 (0.62) | NLRP3FLT1FLT4KDRKMT2A | |
| SCHEMBL7135756 | 0.86 | NLRP3 (0.62) | NLRP3FLT1FLT4KDRALDH1A1 | |
| SCHEMBL7614941 | 0.85 | NLRP3 (0.58) | NLRP3LPAR1 | |
| SCHEMBL7616767 | 0.82 | NLRP3 (0.57) | NLRP3FLT1FLT4KDRKMT2A | |
| SCHEMBL7613834 | 0.82 | NLRP3 (0.57) | NLRP3ALDH1A1MAPTKMT2A | |
| SCHEMBL31135814 | 0.81 | NLRP3 (0.63) | NLRP3FLT1FLT4KDRLPAR1 | |
| SCHEMBL18029650 | 0.81 | NLRP3 (0.63) | NLRP3FLT1FLT4KDRLPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964849-B1 | SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY | PFIZER (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-1270554-A1 | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity | PFIZER INC. (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1270565-A1 | 4-Substituted furan-2-sulfonamide and its use in the preparation of sulfonyl urea derivatives | PFIZER INC. (US) | 2003-01-02 | — | — | EP | disclosed |