Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19002687 | 0.77 | CA2 (0.48) | CA2IDO1CA1CA9PTGES2 | |
| SCHEMBL4980093 | 0.73 | ALDH1A1 (0.37) | POLBKMT2A | |
| SCHEMBL28383723 | 0.70 | CA1 (0.40) | CA2IDO1CA1CA9POLB | |
| SCHEMBL3237778 | 0.70 | CA2 (0.48) | CA2IDO1CA1CA9PTGES2 | |
| SCHEMBL95876 | 0.68 | SLC6A2 (0.47) | LMNACTSKMMP8 | |
| SCHEMBL28181866 | 0.67 | ALDH1A1 (0.37) | CA1CA12CA7LMNACTSS | |
| SCHEMBL515212 | 0.67 | CA2 (0.53) | CA2IDO1CA1CA9CA12 | |
| SCHEMBL3250700 | 0.66 | CA2 (0.48) | CA2IDO1CA1CA9CA12 | |
| SCHEMBL3240066 | 0.66 | CA2 (0.48) | CA2IDO1CA1CA9PTGES2 | |
| SCHEMBL302785 | 0.66 | CA2 (0.69) | CA2IDO1CA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432922-B1 | ANTITUMOR AGENTS; ANGIOGENESIS INHIBITORS | CORVAS INTERNATIONAL, INC. | 2002-08-13 | — | — | US | disclosed |
| EP-1100814-A2 | INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION | CORVAS INTERNATIONAL, INC. (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000005245-A2 | INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION | CORVAS INTERNATIONAL, INC. (US) | 2000-02-03 | — | — | WO | disclosed |