⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7620435 | 0.84 | — | — | |
| SCHEMBL278546 | 0.82 | NOS3 (0.38) | — | |
| SCHEMBL7627737 | 0.81 | — | — | |
| SCHEMBL772467 | 0.79 | GPR84 (0.35) | — | |
| SCHEMBL7622270 | 0.78 | TLR7 (0.32) | — | |
| SCHEMBL439550 | 0.77 | HIF1A (0.35) | — | |
| SCHEMBL7619555 | 0.77 | PTPN7 (0.33) | — | |
| SCHEMBL7619037 | 0.77 | HRH3 (0.34) | — | |
| SCHEMBL7626687 | 0.75 | PTPN7 (0.35) | — | |
| SCHEMBL22833590 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166060-A | 1H-4(5)-substituted imidazole derivatives | GLIATECH, INC. (US) | 2000-12-26 | — | — | US | claimed |
| US-6448282-B1 | H3 HISTAMINE RECEPTOR ANTAGONIST ACTIVITY; ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE, DEPRESSION, SCHIZOPHRENIA, NARCOLEPSY, SLEEP APNEA, INSOMNIA, EPILEPSY, HYPOTHALAMIC DYSFUNCTION | GLIATECH, INC. | 2002-09-10 | — | — | US | disclosed |
| US-6166060-A | 1H-4(5)-substituted imidazole derivatives | GLIATECH, INC. (US) | 2000-12-26 | — | — | US | disclosed |