Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA3 | P15088 | 3/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.43 |
| ▸ | CPA1 | P15085 | 2/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7617132 | 0.85 | CPA3 (0.60) | CPA3FOLH1CYP1A2NAALAD2CPA1 | |
| SCHEMBL7624084 | 0.81 | CPA3 (0.56) | CPA3FOLH1CYP1A2NAALAD2CPA1 | |
| SCHEMBL7622788 | 0.81 | CPA3 (0.52) | CPA3FOLH1CYP1A2NAALAD2CPA1 | |
| SCHEMBL4268844 | 0.79 | CPA3 (0.46) | CPA3FOLH1NAALAD2 | |
| SCHEMBL7625201 | 0.78 | CPA3 (0.54) | CPA3FOLH1NAALAD2KEAP1 | |
| SCHEMBL23705412 | 0.78 | CPA3 (0.56) | CPA3FOLH1CYP1A2NAALAD2CPA1 | |
| SCHEMBL7622966 | 0.77 | CPA3 (0.52) | CPA3FOLH1KEAP1 | |
| SCHEMBL7617124 | 0.76 | CPA3 (0.51) | CPA3FOLH1KEAP1 | |
| SCHEMBL7624082 | 0.75 | CPA3 (0.50) | CPA3FOLH1KEAP1 | |
| SCHEMBL3963424 | 0.74 | CPA3 (1.00) | CPA3FOLH1CYP1A2NAALAD2CPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384022-B1 | ENZYME INHIBITORS | GUILFORD PHARMACEUTICALS INC. | 2002-05-07 | — | — | US | claimed |
| JP-2001527084-A | — | — | 2001-12-25 | — | — | JP | claimed |
| EP-1044206-A1 | PRODRUGS OF NAALADASE INHIBITORS | Guildford Pharmaceuticals Inc. (US) | 2000-10-18 | — | — | EP | claimed |
| WO-1999033849-A1 | PRODRUGS OF NAALADASE INHIBITORS | GUILDFORD PHARMACEUTICALS INC. (US) | 1999-07-08 | — | — | WO | claimed |
| US-6384022-B1 | ENZYME INHIBITORS | GUILFORD PHARMACEUTICALS INC. | 2002-05-07 | — | — | US | disclosed |
| EP-1044206-A1 | PRODRUGS OF NAALADASE INHIBITORS | Guildford Pharmaceuticals Inc. (US) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999033849-A1 | PRODRUGS OF NAALADASE INHIBITORS | GUILDFORD PHARMACEUTICALS INC. (US) | 1999-07-08 | — | — | WO | disclosed |