Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7623817 | 1.00 | SLC18A3 (0.45) | SLC18A3CHRNA7OPRM1OPRK1TSHR | |
| SCHEMBL7620129 | 1.00 | SLC18A3 (0.45) | SLC18A3CHRNA7OPRM1OPRK1TSHR | |
| SCHEMBL7620120 | 1.00 | SLC18A3 (0.45) | SLC18A3CHRNA7OPRM1OPRK1TSHR | |
| SCHEMBL7623805 | 1.00 | SLC18A3 (0.45) | SLC18A3CHRNA7OPRM1OPRK1TSHR | |
| SCHEMBL9496731 | 0.85 | CHRNA7 (0.50) | CHRNA7OPRM1OPRK1 | |
| SCHEMBL9493953 | 0.85 | CHRNA7 (0.50) | CHRNA7OPRM1OPRK1 | |
| SCHEMBL27203809 | 0.81 | SLC9A3 (0.49) | CHRNA7OPRM1OPRK1TSHR | |
| SCHEMBL7625381 | 0.79 | SLC18A3 (0.53) | SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL7620201 | 0.76 | PDPK1 (0.44) | SLC18A3CHRNA7OPRM1OPRK1TSHR | |
| SCHEMBL7620196 | 0.76 | PDPK1 (0.44) | SLC18A3CHRNA7OPRM1OPRK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436954-B1 | BENZO(B)QUINOLIZIDINE AND BENZO(F)INDOLIZIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA OR OTHER CONDITIONS CHARACTERIZED BY MEMORY LOSS; PYRROLO(1,2-B)ISOQUINOLINES, BENZO(B)QUINOLIZINES | AMERICAN BIOGENETIC SCIENCES, INC. | 2002-08-20 | — | — | US | disclosed |