Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7616649 | 0.95 | SLC18A3 (0.50) | SLC18A3CHRNA7OPRM1OPRK1HTR1A | |
| SCHEMBL7616656 | 0.95 | SLC18A3 (0.50) | SLC18A3CHRNA7OPRM1OPRK1HTR1A | |
| SCHEMBL7616665 | 0.95 | SLC18A3 (0.50) | SLC18A3CHRNA7OPRM1OPRK1HTR1A | |
| SCHEMBL12362862 | 0.81 | HTR1A (0.54) | SLC18A3CHRNA7HTR1A | |
| SCHEMBL8165904 | 0.81 | HTR1A (0.54) | SLC18A3CHRNA7HTR1A | |
| SCHEMBL8165906 | 0.81 | HTR1A (0.54) | SLC18A3CHRNA7HTR1A | |
| SCHEMBL7620113 | 0.79 | SLC18A3 (0.45) | SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL7623817 | 0.79 | SLC18A3 (0.45) | SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL7623805 | 0.79 | SLC18A3 (0.45) | SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL7620129 | 0.79 | SLC18A3 (0.45) | SLC18A3CHRNA7OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436954-B1 | BENZO(B)QUINOLIZIDINE AND BENZO(F)INDOLIZIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA OR OTHER CONDITIONS CHARACTERIZED BY MEMORY LOSS; PYRROLO(1,2-B)ISOQUINOLINES, BENZO(B)QUINOLIZINES | AMERICAN BIOGENETIC SCIENCES, INC. | 2002-08-20 | — | — | US | disclosed |