Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clinofibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 11/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | FABP2 | P12104 | 2/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clinofibrate SCHEMBL31290 | 0.84 | ADORA3 (1.00) | ADORA3PPARATSHRPPARGMEN1 | |
| Clinofibrate SCHEMBL20339978 | 0.84 | ADORA3 (1.00) | ADORA3PPARATSHRPPARGMEN1 | |
| Clinofibrate SCHEMBL3955329 | 0.84 | ADORA3 (1.00) | ADORA3PPARATSHRPPARGMEN1 | |
| Clinofibrate SCHEMBL11223466 | 0.83 | ADORA3 (0.97) | ADORA3PPARATSHRPPARGMEN1 | |
| SCHEMBL12918474 | 0.81 | ADORA3 (0.88) | ADORA3PPARALMNATSHRPPARG | |
| SCHEMBL12918479 | 0.81 | ADORA3 (0.92) | ADORA3PPARATSHRPPARGMEN1 | |
| Ciprofibrate SCHEMBL26870 | 0.80 | PPARA (1.00) | PPARALMNACYP2C9TSHRBLM | |
| Ciprofibrate SCHEMBL8164529 | 0.80 | PPARA (1.00) | PPARALMNACYP2C9TSHRBLM | |
| SCHEMBL12918476 | 0.80 | ADORA3 (0.90) | ADORA3PPARATSHRPPARGMEN1 | |
| SCHEMBL28012863 | 0.80 | ADORA3 (0.90) | ADORA3PPARATSHRPPARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235561-A2 | FAST DISSOLVING COMPOSITION WITH PROLONGED SWEET TASTE | Panacea Biotec Limited (IN) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001039749-A2 | FAST DISSOLVING COMPOSITION WITH PROLONGED SWEET TASTE | PANACEA BIOTEC LIMITED (IN) | 2001-06-07 | — | — | WO | disclosed |