Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.98 |
| ▸ | BLM | P54132 | 2/20 | 0.98 |
| ▸ | ESR1 | P03372 | 6/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.75 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.75 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.75 |
| ▸ | DRD1 | P21728 | 1/20 | 0.75 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.75 |
| ▸ | KDR | P35968 | 1/20 | 0.75 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | ATM | Q13315 | 2/20 | 0.72 |
| ▸ | PGR | P06401 | 2/20 | 0.72 |
| ▸ | AR | P10275 | 2/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estramustine SCHEMBL679202 | 1.00 | RECQL (0.98) | RECQLBLMESR1ADORA3INPPL1 | |
| Estramustine SCHEMBL13753350 | 0.99 | RECQL (1.00) | RECQLBLMESR1ADORA3INPPL1 | |
| Estramustine SCHEMBL29374661 | 0.99 | RECQL (1.00) | RECQLBLMESR1ADORA3INPPL1 | |
| Estramustine SCHEMBL2348477 | 0.99 | RECQL (1.00) | RECQLBLMESR1ADORA3INPPL1 | |
| Estramustine SCHEMBL4252 | 0.99 | RECQL (1.00) | RECQLBLMESR1ADORA3INPPL1 | |
| Estramustine SCHEMBL29349776 | 0.99 | RECQL (1.00) | RECQLBLMESR1ADORA3INPPL1 | |
| Estramustine SCHEMBL8173336 | 0.99 | RECQL (1.00) | RECQLBLMESR1ADORA3INPPL1 | |
| Estramustine SCHEMBL7200287 | 0.99 | RECQL (1.00) | RECQLBLMESR1ADORA3INPPL1 | |
| Estramustine SCHEMBL6353316 | 0.99 | RECQL (1.00) | RECQLBLMESR1ADORA3INPPL1 | |
| Estramustine SCHEMBL14031683 | 0.99 | RECQL (1.00) | RECQLBLMESR1ADORA3INPPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096067-A1 | DROSOPHILA TUMOR STEM CELL MODEL AND USES THEREOF | PERRIMON NORBERT (US) | 2013-04-18 | — | — | US | disclosed |
| EP-0730474-B1 | ESTRAMUSTINE FORMULATIONS WITH IMPROVED PHARMACEUTICAL PROPERTIES | PHARMACIA & UPJOHN AB (SE) | 2002-06-19 | — | — | EP | disclosed |
| US-5712260-A | WITH CYCLODEXTRIN, IMPROVED BIOAVAILABILITY, ADMINISTERING BY MOUTH, ADVANCED TUMOR TREATMENT | PHARMACIA AB (SE) | 1998-01-27 | — | — | US | disclosed |
| EP-0730474-A1 | ESTRAMUSTINE FORMULATIONS WITH IMPROVED PHARMACEUTICAL PROPERTIES | Pharmacia AB (SE) | 1996-09-11 | — | — | EP | disclosed |
| WO-1996009072-A1 | ESTRAMUSTINE FORMULATIONS WITH IMPROVED PHARMACEUTICAL PROPERTIES | PHARMACIA AB (SE) | 1996-03-28 | — | — | WO | disclosed |