⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7630023 | 0.85 | AGTR1 (0.54) | — | |
| SCHEMBL7631340 | 0.84 | AGTR1 (0.47) | — | |
| SCHEMBL9707118 | 0.83 | AGTR1 (0.41) | — | |
| SCHEMBL8412607 | 0.80 | AGTR1 (0.43) | — | |
| SCHEMBL7631932 | 0.80 | AGTR1 (0.52) | — | |
| SCHEMBL7628758 | 0.77 | AGTR1 (0.41) | — | |
| SCHEMBL7628776 | 0.77 | AGTR1 (0.40) | — | |
| SCHEMBL7630092 | 0.76 | — | — | |
| SCHEMBL7624923 | 0.75 | AGTR1 (0.57) | — | |
| SCHEMBL7623723 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451833-B1 | ANGIOTENSIN ANTAGONISTS | PHARMACIA CORPORATION | 2002-09-17 | — | — | US | claimed |
| US-5451597-A | Hypotensive agents, congestive heart failure | G.D. SEARLE & CO. (US) | 1995-09-19 | — | — | US | claimed |
| WO-1992015577-A1 | N-SUBSTITUTED (ALPHA-IMIDAZOLYL-TOLUYL) PYRROLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-09-17 | — | — | WO | claimed |
| US-6451833-B1 | ANGIOTENSIN ANTAGONISTS | PHARMACIA CORPORATION | 2002-09-17 | — | — | US | disclosed |
| US-6008368-A | USEFUL FOR TREATING HYPERTENSION AND CONGESTIVE HEART FAILURE; NONPEPTIDIC | G. D. SEARLE & CO. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5451597-A | Hypotensive agents, congestive heart failure | G.D. SEARLE & CO. (US) | 1995-09-19 | — | — | US | disclosed |
| US-5187271-A | Hypotensive agents, cardiovascular disorders | G. D. SEARLE & CO. (US) | 1993-02-16 | — | — | US | disclosed |
| WO-1992015577-A1 | N-SUBSTITUTED (ALPHA-IMIDAZOLYL-TOLUYL) PYRROLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-09-17 | — | — | WO | disclosed |