Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7622240 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTKDM4EALDH1A1HTT | |
| SCHEMBL7622242 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTKDM4EALDH1A1HTT | |
| SCHEMBL7516937 | 0.77 | MEN1 (0.37) | ALDH1A1KMT2A | |
| SCHEMBL2993089 | 0.76 | HSD11B1 (0.46) | SMN1; SMN2ALDH1A1KMT2ALMNATSHR | |
| SCHEMBL15114606 | 0.73 | CHRM2 (0.39) | SMN1; SMN2ALDH1A1L3MBTL1GAA | |
| SCHEMBL22481540 | 0.69 | HSD11B1 (0.33) | — | |
| Bromide SCHEMBL7619351 | 0.68 | MAPT (0.38) | SMN1; SMN2MAPTKDM4EALDH1A1HTT | |
| Bromide SCHEMBL7619343 | 0.68 | MAPT (0.38) | SMN1; SMN2MAPTKDM4EALDH1A1HTT | |
| Bromide SCHEMBL7619347 | 0.68 | MAPT (0.38) | SMN1; SMN2MAPTKDM4EALDH1A1HTT | |
| SCHEMBL2457242 | 0.67 | FPR2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620225-B1 | Cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2002-11-13 | — | — | EP | disclosed |
| US-5523400-A | 3-(PYRROLIDIN-3-YLIDENE=CH-),7-((2-AMINOTHIAZOL-4-YL)HYDROX -IMINOACETYLAMINO-)-3-CEPHEM DERIVATIVES; BROAD SPECTRUM ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0620225-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-10-19 | — | — | EP | disclosed |