Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 7/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7147007 | 0.95 | NLRP3 (0.63) | NLRP3 | |
| SCHEMBL7621828 | 0.86 | CA2 (0.53) | NLRP3CA2 | |
| SCHEMBL7137327 | 0.80 | NLRP3 (0.52) | NLRP3CA2 | |
| SCHEMBL7619071 | 0.79 | NLRP3 (0.71) | NLRP3CA2 | |
| SCHEMBL7137679 | 0.79 | NLRP3 (0.66) | NLRP3CA2 | |
| SCHEMBL7142139 | 0.77 | NLRP3 (0.79) | NLRP3 | |
| SCHEMBL7139273 | 0.76 | NLRP3 (0.48) | NLRP3 | |
| SCHEMBL7139277 | 0.76 | NLRP3 (0.48) | NLRP3 | |
| SCHEMBL19505698 | 0.76 | NLRP3 (0.48) | NLRP3 | |
| SCHEMBL7622551 | 0.73 | NLRP3 (0.60) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214087-A1 | COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE | Pfizer Products Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019390-A1 | COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-03-22 | — | — | WO | disclosed |