Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.60 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7623168 | 0.90 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL7622763 | 0.86 | AGTR1 (0.61) | AGTR1AGTR2 | |
| SCHEMBL7628739 | 0.83 | AGTR1 (0.64) | AGTR1AGTR2 | |
| SCHEMBL159 | 0.81 | AGTR1 (0.81) | AGTR1AGTR2 | |
| SCHEMBL9269068 | 0.78 | AGTR1 (0.67) | AGTR1AGTR2 | |
| SCHEMBL11100306 | 0.78 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL352 | 0.77 | AGTR1 (0.64) | AGTR1AGTR2 | |
| SCHEMBL7630023 | 0.76 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL984922 | 0.76 | AGTR1 (0.63) | AGTR1AGTR2 | |
| SCHEMBL201 | 0.76 | AGTR1 (0.63) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451833-B1 | ANGIOTENSIN ANTAGONISTS | PHARMACIA CORPORATION | 2002-09-17 | — | — | US | disclosed |
| US-6008368-A | USEFUL FOR TREATING HYPERTENSION AND CONGESTIVE HEART FAILURE; NONPEPTIDIC | G. D. SEARLE & CO. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5451597-A | Hypotensive agents, congestive heart failure | G.D. SEARLE & CO. (US) | 1995-09-19 | — | — | US | disclosed |
| US-5187271-A | Hypotensive agents, cardiovascular disorders | G. D. SEARLE & CO. (US) | 1993-02-16 | — | — | US | disclosed |
| WO-1992015577-A1 | N-SUBSTITUTED (ALPHA-IMIDAZOLYL-TOLUYL) PYRROLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-09-17 | — | — | WO | disclosed |