SCHEMBL984922

SCHEMBL984922

CCCCc1nc(Cl)c(CO)n1Cc1ccc(Br)cc1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.63
AGTR2 P50052 3/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14169314 0.90 AGTR1 (0.56) AGTR1AGTR2
SCHEMBL352 0.88 AGTR1 (0.64) AGTR1AGTR2
SCHEMBL201 0.87 AGTR1 (0.63) AGTR1AGTR2
SCHEMBL11100306 0.87 AGTR1 (0.72) AGTR1AGTR2
SCHEMBL3874586 0.85 AGTR1 (0.61) AGTR1AGTR2
SCHEMBL16456600 0.84 AGTR1 (0.63) AGTR1AGTR2
SCHEMBL653 0.84 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL159 0.84 AGTR1 (0.81) AGTR1AGTR2
SCHEMBL276 0.84 AGTR1 (0.60) AGTR1AGTR2
SCHEMBL156 0.82 AGTR1 (0.58) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7041832-B2 Processes for preparing losartan and losartan potassium TAVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) 2006-05-09 US claimed
EP-1474417-B1 PROCESSES FOR PREPARING LOSARTAN AND LOSARTAN POTASSIUM TEVA PHARMA (IL) 2006-03-22 EP claimed
US-20040034077-A1 Processes for preparing losartan and losartan an potassium TEVA PHARMACEUTICALS INDUSTRIES, LTD. (IL) 2004-02-19 US claimed
EP-0643704-B1 TETRAZOLYLPHENYLBORONIC ACID INTERMEDIATES FOR THE SYNTHESIS OF AII RECEPTOR ANTAGONISTS DU PONT (US) 2003-09-17 EP claimed
US-20120046471-A1 PROCESS FOR PREPARING ORGANIC COMPOUNDS BY A TRANSITION METAL-CATALYSED CROSS-COUPLING REACTION OF AN ARYL-X, HETEROARYL-X, CYCLOALKENYL-X OR ALKENYL-X COMPOUND WITH AN ALKYL, ALKENYL, CYCLOALKYL OR CYCLOALKENYL HALIDE SALTIGO GMBH (DE) 2012-02-23 US disclosed
US-20120046471-A1 PROCESS FOR PREPARING ORGANIC COMPOUNDS BY A TRANSITION METAL-CATALYSED CROSS-COUPLING REACTION OF AN ARYL-X, HETEROARYL-X, CYCLOALKENYL-X OR ALKENYL-X COMPOUND WITH AN ALKYL, ALKENYL, CYCLOALKYL OR CYCLOALKENYL HALIDE SALTIGO GMBH (DE) 2012-02-23 US disclosed
US-8030520-B2 Process for preparing organic compounds by a transition metal-catalysed cross-coupling reaction of an aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide SALTIGO GMBH (DE) 2011-10-04 US disclosed
US-8030520-B2 Process for preparing organic compounds by a transition metal-catalysed cross-coupling reaction of an aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide SALTIGO GMBH (DE) 2011-10-04 US disclosed
US-7915425-B2 Process for the preparation of losartan SUVEN LIFE SCIENCES LIMITED (IN) 2011-03-29 US disclosed
US-7868180-B2 Process for the preparation of sartan derivatives and intermediates useful in such process KRKA, D.D. NOVO MESTO (SI) 2011-01-11 US disclosed
US-20100222597-A1 Process for the preparation of losartan SUVEN LIFE SCIENCES LIMITED (IN) 2010-09-02 US disclosed
US-20090247764-A1 PROCESS FOR PREPARING ORGANIC COMPOUNDS BY A TRANSITION METAL-CATALYSED CROSS-COUPLING REACTION OF AN ARYL-X, HETEROARYL-X, CYCLOALKENYL-X OR ALKENYL-X COMPOUND WITH AN ALKYL, ALKENYL, CYCLOALKYL OR CYCLOALKENYL HALIDE SALTIGO GMBH (DE) 2009-10-01 US disclosed
WO-1995026724-A1 IMPROVEMENT OF INSULIN SENSITIVITY WITH ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES EIDE IVAR KONRAD (NO) 1995-10-12 WO disclosed
WO-1995026188-A1 TREATMENT OF ATHEROSCLEROSIS WITH ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES MERCK & CO., INC. (US) 1995-10-05 WO disclosed
WO-1995017396-A1 POLYMORPHS OF LOSARTAN AND THE PROCESS FOR THE PREPARATION OF FORM II OF LOSARTAN MERCK & CO., INC. (US) 1995-06-29 WO disclosed
EP-0643704-A4 TETRAZOLYLPHENYLBORONIC ACID INTERMEDIATES FOR THE SYNTHESIS OF AII RECEPTOR ANTAGONISTS. 1995-04-12 EP disclosed
EP-0643704-A1 TETRAZOLYLPHENYLBORONIC ACID INTERMEDIATES FOR THE SYNTHESIS OF AII RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-03-22 EP disclosed
US-5310928-A Process for preparing biphenyltetrazole compounds E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-05-10 US disclosed
WO-1993010106-A1 TETRAZOLYLPHENYLBORONIC ACID INTERMEDIATES FOR THE SYNTHESIS OF AII RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-05-27 WO disclosed
US-5206374-A Process for preparing tetrazolylphenylboronic acid intermediates E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247764-A1 PROCESS FOR PREPARING ORGANIC COMPOUNDS BY A TRANSITION METAL-CATALYSED CROSS-COUPLING REACTION OF AN ARYL-X, HETEROARYL-X, CYCLOALKENYL-X OR ALKENYL-X COMPOUND WITH AN ALKYL, ALKENYL, CYCLOALKYL OR CYCLOALKENYL HALIDE MLX, PYM1, CBR3 AGTR1 930/4885AGTR2 1258/4885
US-20040034077-A1 Processes for preparing losartan and losartan an potassium REN, ACE, AGT AGTR1 4/4885AGTR2 6/4885
US-20120046471-A1 PROCESS FOR PREPARING ORGANIC COMPOUNDS BY A TRANSITION METAL-CATALYSED CROSS-COUPLING REACTION OF AN ARYL-X, HETEROARYL-X, CYCLOALKENYL-X OR ALKENYL-X COMPOUND WITH AN ALKYL, ALKENYL, CYCLOALKYL OR CYCLOALKENYL HALIDE TIMCC, ZFX, TSNAX AGTR1 1347/4885AGTR2 1800/4885
US-20100222597-A1 Process for the preparation of losartan AGT, ACE, AGTR1 AGTR1 3/4885AGTR2 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.