Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 6/20 | 0.45 |
| ▸ | METAP1 | P53582 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7620135 | 0.95 | METAP1 (0.47) | CHRNA7ACHEMETAP1KMT2A | |
| SCHEMBL4525381 | 0.81 | METAP1 (0.49) | CHRNA7ACHEMETAP1 | |
| SCHEMBL15715919 | 0.78 | METAP1 (0.56) | CHRNA7ACHEMETAP1 | |
| SCHEMBL29828351 | 0.75 | CHRNA7 (0.71) | CHRNA7 | |
| SCHEMBL7622785 | 0.74 | METAP1 (0.41) | METAP1 | |
| SCHEMBL11859478 | 0.73 | KDM4E (0.56) | CHRNA7KMT2A | |
| SCHEMBL7620065 | 0.72 | CHRNA7 (0.39) | CHRNA7 | |
| SCHEMBL11859219 | 0.72 | HDAC6 (0.53) | CHRNA7 | |
| SCHEMBL7616373 | 0.71 | ACHE (0.52) | ACHEMETAP1 | |
| Hydrochloric Acid SCHEMBL11861733 | 0.71 | HDAC6 (0.52) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436954-B1 | BENZO(B)QUINOLIZIDINE AND BENZO(F)INDOLIZIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA OR OTHER CONDITIONS CHARACTERIZED BY MEMORY LOSS; PYRROLO(1,2-B)ISOQUINOLINES, BENZO(B)QUINOLIZINES | AMERICAN BIOGENETIC SCIENCES, INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1098650-A1 | BENZOQUINOLIZIDINE AND BENZOINDOLIZIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004905-A1 | BENZOQUINOLIZIDINE AND BENZOINDOLIZIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2000-02-03 | — | — | WO | disclosed |