Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CHRNG | P07510 | 1/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRND | Q07001 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL28409961 | 0.88 | SLC7A5 (0.52) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL11404585 | 0.88 | SLC7A5 (0.57) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL10722619 | 0.87 | SLC7A5 (0.44) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL10720159 | 0.87 | SLC7A5 (0.44) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL6130126 | 0.87 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL22400727 | 0.87 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL222260 | 0.87 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL9551454 | 0.86 | SLC7A5 (0.55) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL20377367 | 0.85 | SLC7A5 (0.63) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL27692297 | 0.85 | THRB (0.44) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10182489-A | — | — | None | — | — | JP | disclosed |
| EP-0848013-B1 | NM03, a monoclonal antibody to HIV-1 gp120 protein | NISSIN FOOD PRODUCTS LTD (JP) | 2002-04-03 | — | — | EP | disclosed |
| JP-H10182489-A | MONOCLONAL ANTIBODY | NISSIN FOOD PROD CO LTD | 1998-07-07 | — | — | JP | disclosed |
| EP-0848013-A1 | NM03, a monoclonal antibody to HIV-1 gp120 protein | NISSIN SHOKUHIN KABUSHIKI KAISHA (JP) | 1998-06-17 | — | — | EP | disclosed |
| US-5618922-A | MONOCLONAL ANTIBODY TREATING HIV PATIENT | NISSIN SHOKUHIN KABUSHIKI KAISHA (JP) | 1997-04-08 | — | — | US | disclosed |