Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 3/20 | 0.56 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.56 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 10/20 | 0.40 |
| ▸ | DRD3 | P35462 | 10/20 | 0.40 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.32 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232595 | 0.89 | ABCC9 (0.54) | ABCC9ABCC8KCNJ11KCNJ8DRD2 | |
| SCHEMBL6434255 | 0.84 | ABCC9 (0.77) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL7625050 | 0.82 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8TSHR | |
| SCHEMBL6905395 | 0.80 | ABCC9 (0.77) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL6431754 | 0.80 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11KCNJ8DRD2 | |
| SCHEMBL5079077 | 0.78 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL6909574 | 0.78 | ABCC9 (0.70) | ABCC9ABCC8KCNJ11KCNJ8DRD2 | |
| SCHEMBL7836158 | 0.77 | ABCC9 (0.84) | ABCC9ABCC8KCNJ11KCNJ8NOTCH1 | |
| SCHEMBL7623743 | 0.76 | ABCC9 (0.52) | ABCC9ABCC8KCNJ11KCNJ8DRD2 | |
| SCHEMBL7620062 | 0.73 | MAPT (0.41) | CYP2D6TSHRNFKB1CACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | claimed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | claimed |