Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742791 | 1.00 | GAA (0.55) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL27042699 | 0.90 | SMN1; SMN2 (0.50) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL742852 | 0.88 | STS (0.48) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL742851 | 0.88 | STS (0.48) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL17533942 | 0.85 | HDAC1 (0.62) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL762580 | 0.85 | HDAC1 (0.62) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL19378084 | 0.85 | HDAC1 (0.62) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL28685994 | 0.83 | ACHE (0.65) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL28685992 | 0.83 | ACHE (0.65) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL4101109 | 0.81 | KMT2A (0.57) | GAAMAPTSMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |