Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.48 |
| ▸ | RARA | P10276 | 9/20 | 0.43 |
| ▸ | RARB | P10826 | 8/20 | 0.43 |
| ▸ | RARG | P13631 | 8/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7618529 | 0.85 | RARA (0.43) | TNKSRARARARBRARGKDM4E | |
| SCHEMBL7622689 | 0.85 | RARA (0.43) | TNKSRARARARBRARGKDM4E | |
| SCHEMBL7618545 | 0.85 | TNKS (0.48) | TNKSRARARARBRARGNQO2 | |
| SCHEMBL29367158 | 0.82 | RARA (0.62) | RARARARBRARG | |
| SCHEMBL1132581 | 0.82 | RARA (0.62) | RARARARBRARG | |
| SCHEMBL7952350 | 0.81 | RARA (0.41) | TNKSRARARARBRARGNQO2 | |
| SCHEMBL7730938 | 0.81 | RARA (0.43) | TNKSRARARARBRARGTTR | |
| SCHEMBL7725609 | 0.81 | RARA (0.41) | TNKSRARARARBRARGTTR | |
| SCHEMBL7624863 | 0.81 | MAOB (0.51) | RARARARBRARGNQO2POLB | |
| SCHEMBL3487237 | 0.80 | KDM5A (0.49) | TNKSRARARARBRARGNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358995-B1 | AGONIST FOR RETINOIC ACID RECEPTORS; CAN BE SUBSTITUTED FOR RETINOIC ACID AS PREVENTIVE AND THERAPEUTIC DRUGS FOR VARIOUS DISEASES OR CANCERS, SUCH AS ACUTE PROMYELOCYTIC LEUKEMIA. | EISAI CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6355669-B1 | THERAPY FOR KIDNEY DISEASE USING BENZOIC ACID COMPOUND | EISAI CO., LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| US-6258811-B1 | ADMINISTERING RETINOIC ACID RECEPTOR AGONIST | EISAI CO., LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| US-6121309-A | SUCH AS 4-(2-(5-(7-FLUORO-4-TRIFLUOROMETHYLBENZOFURAN-2-YL)PYRROLYL)) BENZOIC ACID; RETINOIC ACID RECEPTOR AGONISM | EISAI CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6110959-A | A RETINOIC ACID RECEPTOR AGONIST | EISAI CO., LTD. (JP) | 2000-08-29 | — | — | US | disclosed |
| EP-1025857-A1 | RETINOIC ACID AGONISTS AS PREVENTIVE AND THERAPEUTIC AGENTS FOR NEPHRITIS | Eisai Co., Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |
| EP-0930075-A1 | METHODS FOR PREVENTING, INHIBITING OR TREATING GRAFT REJECTION REACTIONS IN GRAFT-VERSUS-HOST DISEASE (GVHD) AND ORGAN TRANSPLANTATION | Eisai Co., Ltd. (JP) | 1999-07-21 | — | — | EP | disclosed |
| EP-0889032-A1 | FUSED-RING CARBOXYLIC ACID DERIVATIVES | Eisai Co., Ltd. (JP) | 1999-01-07 | — | — | EP | disclosed |