Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 12/20 | 0.44 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7629232 | 0.86 | LCK (0.45) | LCKCISD2 | |
| SCHEMBL7626056 | 0.84 | LCK (0.45) | LCK | |
| SCHEMBL6058057 | 0.82 | LCK (0.53) | LCKMAPT | |
| SCHEMBL7631046 | 0.80 | LCK (0.70) | LCK | |
| SCHEMBL7635519 | 0.80 | LCK (0.57) | PKMLCK | |
| SCHEMBL7626156 | 0.79 | PKM (0.53) | PKMLCKCISD2 | |
| SCHEMBL7631673 | 0.78 | LCK (0.46) | PKMLCKMEN1KMT2A | |
| SCHEMBL7632520 | 0.77 | LCK (0.43) | PKMLCKMEN1KMT2A | |
| SCHEMBL6608789 | 0.76 | LCK (0.66) | LCKCISD2 | |
| SCHEMBL7625987 | 0.76 | LCK (0.45) | LCKCISD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037632-A4 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1037632-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999024035-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-05-20 | — | — | WO | disclosed |