Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 3/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 10/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7625995 | 0.91 | ILK (0.66) | ILKAPPLCKDYRK1AKDM4E | |
| SCHEMBL7628404 | 0.82 | ILK (0.65) | ILKAPPLCKDYRK1AKDM4E | |
| SCHEMBL5130365 | 0.76 | MAPT (0.55) | ILKAPPKDM4ELMNASMN1; SMN2 | |
| SCHEMBL687425 | 0.76 | ILK (0.73) | ILKAPPDYRK1AKDM4ELMNA | |
| SCHEMBL2055271 | 0.74 | DYRK1A (0.58) | ILKAPPDYRK1AKDM4ELMNA | |
| SCHEMBL8574737 | 0.74 | DYRK1A (0.62) | ILKAPPDYRK1AKDM4ESMN1; SMN2 | |
| SCHEMBL2854505 | 0.73 | KDM4E (0.68) | APPKDM4ELMNANFKB1NFKB2 | |
| SCHEMBL29858067 | 0.71 | KDM4E (0.61) | ILKAPPDYRK1AKDM4ELMNA | |
| SCHEMBL30563648 | 0.71 | ILK (0.54) | ILKAPPDYRK1AKDM4ELMNA | |
| SCHEMBL6058064 | 0.70 | LCK (0.71) | LCKFYNSRCHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037632-A4 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1037632-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999024035-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-05-20 | — | — | WO | disclosed |