Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 3/20 | 0.65 |
| ▸ | APP | P05067 | 3/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7625995 | 0.90 | ILK (0.66) | ILKAPPDYRK1AKDM4ENPC1 | |
| SCHEMBL7628652 | 0.82 | ILK (0.60) | ILKAPPDYRK1AKDM4ENPC1 | |
| SCHEMBL687425 | 0.80 | ILK (0.73) | ILKAPPDYRK1AKDM4ENPC1 | |
| SCHEMBL2854505 | 0.80 | KDM4E (0.68) | APPKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8574737 | 0.78 | DYRK1A (0.62) | ILKAPPDYRK1AKDM4ENPC1 | |
| SCHEMBL29858067 | 0.78 | KDM4E (0.61) | ILKAPPDYRK1AKDM4ENPC1 | |
| SCHEMBL3113684 | 0.73 | RAB9A (0.61) | ILKDYRK1AKDM4ENPC1RAB9A | |
| SCHEMBL28247185 | 0.73 | DYRK1A (0.60) | ILKAPPDYRK1AKDM4ENPC1 | |
| SCHEMBL30017067 | 0.73 | DYRK1A (0.60) | ILKAPPDYRK1AKDM4ENPC1 | |
| SCHEMBL14451013 | 0.73 | KDM4E (0.54) | ILKAPPKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037632-A4 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1037632-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999024035-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-05-20 | — | — | WO | disclosed |