Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763266 | 0.93 | KLK5 (0.35) | HRH2HRH1KLK5ACEKMT2A | |
| SCHEMBL741369 | 0.92 | MMEL1 (0.38) | HRH1KMT2AITGB3ITGA2BMMEL1 | |
| SCHEMBL763858 | 0.90 | KCNH2 (0.42) | HRH2HRH1KLK5ACE | |
| SCHEMBL762504 | 0.90 | HRH1 (0.37) | HRH2HRH1KLK5ACEUSP30 | |
| SCHEMBL763793 | 0.88 | HRH1 (0.40) | HRH1 | |
| SCHEMBL740291 | 0.87 | DPP4 (0.37) | HRH2HRH1KMT2A | |
| SCHEMBL740290 | 0.87 | DPP4 (0.37) | HRH2HRH1KMT2A | |
| SCHEMBL739547 | 0.86 | HRH1 (0.41) | HRH2HRH1KLK5PADI4 | |
| SCHEMBL739548 | 0.86 | HRH1 (0.41) | HRH2HRH1KLK5PADI4 | |
| SCHEMBL762673 | 0.86 | HRH1 (0.41) | HRH2HRH1KLK5ACEUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |