Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120959 | 0.91 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL6169942 | 0.83 | PTGS2 (0.52) | PTGS2PTGS1MAPTKDM4EMEN1 | |
| SCHEMBL6171078 | 0.80 | PTGS2 (0.56) | PTGS2PTGS1MAPTKDM4EMEN1 | |
| SCHEMBL6171269 | 0.80 | PTGS2 (0.52) | PTGS2PTGS1MAPTKDM4EMEN1 | |
| SCHEMBL6170615 | 0.80 | PTGS2 (0.48) | PTGS2PTGS1MAPTKDM4EMEN1 | |
| SCHEMBL7629983 | 0.80 | MAPT (0.49) | PTGS2PTGS1MAPTKDM4EMEN1 | |
| SCHEMBL6168630 | 0.80 | PTGS2 (0.48) | PTGS2PTGS1MAPTKDM4EMEN1 | |
| SCHEMBL6170413 | 0.78 | KDM4E (0.60) | PTGS2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL9449420 | 0.77 | KDM4E (0.71) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6168395 | 0.77 | PTGS2 (0.53) | PTGS2PTGS1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476042-B1 | Combination therapy for the treatment of migraine | PFIZER INC. | 2002-11-05 | — | — | US | claimed |